If a 6S 22Ah lipo goes up, it’s a bomb. I’ve had 2 friends lose their homes from lipos much smaller than these (4S 1.5Ah, drone racing lipos). I have fudged it with lipos that were just over the 100Wh limit, but one of those is still manageable in an enclosed space. Bonka lipos at almost 500Wh (and if there’s 4 of them 2000Wh packed next to each other), you’re not stopping it once it starts.
Any lipo should always be in carry on, then you can deal with them if they do go up. The dangerous goods declaration you make as you’re checking in says “do you have all spare batteries in your carry on?” Very unlikely that they would go up as long as they’re well cared for, but I don’t want to be the one responsible for 2000Wh of lipo going up in a plane cabin.
Best option is to ship them ahead. Might be a bit more expensive depending on where you’re going.